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Publications
Chembio has several researchers on its' team. The following are links to a list of their publications:

Javan Esfandiari, Senior Vice President, R&D

Konstantin Lyashchenko, Research Director

Rena Greenwald, Research Scientist

Poster Presentations		  
Konstantin Lyashchenko, PhD, Research Director  

  1. U. Wernery, J. Kinne, K.L. Jahans, H.M. Vordermeier, J. Esfandiari, R. Greenwald, B. Johnson, A. Ul-Haq, K.P. Lyashchenko Tuberculosis outbreak in a dromedary racing herd and rapid serological detection of infected camels. Veterinary Microbiology 122 (2007) 108-115.

  2. Lyashchenko K.P., Greenwald R., Esfandiari J., Olsen J.H., Ball R., Dumonceaux G., Dunker F., Buckley C., Richard M., Murray S., Payeur J.B., Andersen P., Pollock J.M., Mikota S., Miller M., Sofranko D., and Waters W.R. 2006. Tuberculosis in elephants: antibody responses to defined antigens of Mycobacterium tuberculosis, potential for early diagnosis, and monitoring of treatment. Clin. Vaccine Immunol. 13: 722-732 
  3. Waters W.R., Palmer M.V., Thacker T.C., Bannantine J.P., Vordermeier H.M., Hewinson R.G., Greenwald R., Esfandiari J., McNair J., Pollock J.M., Andersen P., and Lyashchenko K.P. 2006. Early antibody responses to experimental Mycobacterium bovis infection of cattle. Clin. Vaccine Immunol. 13: 648-654.

  4. Waters W.R., Palmer M.V., Thacker T.C., Payeur J.B., Harris N.B., Minion F.C., Greenwald R., Esfandiari J., Andersen P., McNair J., Pollock J.M., and Lyashchenko K.P. 2006. Immune responses to defined antigens of Mycobacterium bovis in cattle experimentally infected with Mycobacterium kansasii. Clin. Vaccine Immunol. 13: 611-619.

  5. Palmer M.V., Waters W.R., Thacker T.C., Greenwald R., Esfandiari J., and Lyashchenko K.P. 2006. Effects of tuberculin skin-testing regimens on gamma interferon and antibody responses in cattle experimentally infected with Mycobacterium bovis. Clin. Vaccine Immunol. 13: 387-394.

  6. Waters W.R., Pamer M.V., Bannantine J.P., Greenwald R., Esfandiari J., Andersen P., McNair J., Pollock J.M., and Lyashchenko K.P. 2005. Antibody responses in reindeer (Rangifer tarandus) infected with Mycobacterium bovis. Clin. Diagn. Lab. Immunol. 12: 727-735.

  7. Langermans J.A., Doherty T.M., Vervenne R.A., van der Laan T., Lyashchenko K., Greenwald R., Agger E.M., Aagaard C., Weiler H., van Soolingen D., Dalemans W., Thomas A.W., and Andersen P. 2005. Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine 23: 2740-2750.

  8. Waters W.R., Palmer M.V., Bannantine J.P., Whipple D.L., Greenwald R., Esfandiari J., Andersen P., McNair J., Pollock J.M., and Lyashchenko K.P.  2004. Antigen recognition by serum antibodies in white-tailed deer (Odocoileus virginianus) experimentally infected with Mycobacterium bovis. Clin. Diagn. Lab. Immunol. 11: 849-855.

  9. Lyashchenko K., Whelan A.O., Greenwald R., Pollock J.M., Andersen P., Hewinson R.G., and Vordermeier H.M. 2004. Association of tuberculin-boosted antibody responses with pathology and cell-mediated immunity in cattle vaccinated with Mycobacterium bovis BCG and infected with M. bovis. Infec. Immun. 72: 2462-2467.

  10. Greenwald R., Esfandiari J., Lesellier S., Houghton R., Pollock J., Aagaard C., Andersen P., Hewinson R.G., Chambers M., and Lyashchenko K. 2003. Improved serodetection of Mycobacterium bovis infection in badgers (Meles meles) using multiantigen formats. Diagn. Microbiol. Infect. Dis. 46: 197-203.

  11. Rollinck-Werninghaus C., Magdorf K., Stark K., Lyashchenko K., Gennaro M.L., Colangeli R., Doherty T.M., Andersen P., Plum G., Herz U., Renz H., and Wahn U. 2003. The potential of recombinant antigens ESAT-6, MPT63 and mig for specific discrimation of Mycobacterium tuberculosis and M. avium infection. Eur. J. Pediatr. 162: 534-536.

  12. Chandramuki A., Lyashchenko K., Kumari H.B., Khanna N., Brusasca P., Gourie-Devi M., Satishchandra P., Shankar S.K. Ravi V., Alcabes P., Kanaujia G.V., and Gennaro M.L. 2002. Detection of antibody to Mycobacterium tuberculosis protein antigens in the cerebrospinal fluid of patients with tuberculous meningitis. J. Infect. Dis. 186: 678-683.

  13. Houghton R.L., Lodes M.J., Dillon D.C., Reynolds L.D., Day C.H., McNeill P.D., Hendrickson R.C., Skeiky Y.A.W., Sampaio D.P., Badaro R., Lyashchenko K.P., and Reed S.G. 2002. Use of multiepitope polyproteins in serodiagnosis of active tuberculosis. Clin. Diagn. Lab. Immunol. 9: 883-891.

  14. Amadori M., Lyashchenko K.P., Gennaro M.L., Pollock J.M., and Zerbini I. 2002. Use of recombinant proteins in antibody tests for bovine tuberculosis. Vet. Microbiol. 85: 379-389.

  15. Johnson S., Brusasca P., Lyashchenko K., Spencer J.S., Wiker H.G., Bifani P., Shashkina E., Kreiswirth B., Harboe M., Schluger N., Gomex M., and Gennaro M.L. 2001. Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis. Infect. Immun. 69: 5936-5939.

  16. Lyashchenko K.P., Wiker H.G., Harboe M., McNair J., Komissarenko S.V., and Pollock J.M. 2001. Novel monoclonal antibodies against major antigens of Mycobacterium bovis. Scand. J. Immunol. 53: 498-502.

  17. Brusasca P., Colangeli R., Lyashchenko K.P., Zhao X., Vogelstein M., Spencer J.S., McMurray D.N., and Gennaro M.L 2001. Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome. Scan. J. Immunol. 54: 448-452.

  18. Lyashchenko K.P., Singh M., Colangeli R., and Gennaro M.L. 2000. A multiantigen print immunoassay for the serological diagnosis of infectious diseases. J. Immunol. Methods 242: 91-100.

  19. Colangeli R., Spencer J.S., Bifani P., Williams A., Lyashchenko K., Keen M.A., Hill P.J., Belisle J., and Gennaro M.L. 2000. MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis, specific delayed-type hypersensitivity in guinea pigs. Infect. Immun. 68: 990-993.

  20. Colangeli R., Antinori A., Cingolani A., Ortona L., Lyashchenko K., Fadda G., and Gennaro M.L. 1999. Humoral immune responses to multiple antigens of Mycobacterium tuberculosis in tuberculosis patiens co-infected with human immunodeficiency virus. Int. J. Tuberc. Lung Dis. 3: 1127-1131.

  21. Lyashchenko K.P., Pollock J.M., Colangeli R., and Gennaro M.L. 1998. Diversity of antigen recognition by serum antibodies in experimental bovine tuberculosis. Infect. Immun. 66: 5344-5349.

  22. Colangeli R., Heijbel A., Williams A., Manca C., Chan J., Lyashchenko K., and Gennaro M.L. 1998. Three-step purification of lipopolysaccharide-free, polyhistidine-tagged recombinant antigens of Mycobacterium tuberculosis. J., Chromatogr. B. 714: 223-235.

  23. Lyashchenko K., Manca C., Colangeli R., Heijbel A., Williams A., and Gennaro M.L. 1998. Use of Mycobacterium tuberculosis complex-specific antigen cocktails for a skin test specific for tuberculosis. Infect. Immun. 66: 3606-3610.

  24. Lyashchenko K., Colangeil R., Houde M., Jahdali H.A., Menzies D., and Gennaro M.L. 1998. Heterogeneous antibody responses in tuberculosis. Infect. Immun. 66: 3936-3940.

  25. Wiker H.G., Lyashchenko K.P., Aksov A.M., Lightbody K.A., Pollock J.M., Bobrovnik S.O., Kolesnikova I.N., Mykhalsky L.O., Komissarenko S.V., Gennaro M.L., and Harboe M. 1998. Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterum bovis. Infect. Immun. 66: 1445-1452.

  26. Manca C., Lyashchenko K., Colangeli R., and Gennaro M.L. 1997. MTC28, a novel 28-kilodalton proline-rich secreted antigen specific for the Mycobacterium tuberculosis complex. Infect. Immun. 65: 4951-4957.

  27. Manca C., Lyashchenko K., Wiker H.G., Usai D., Colangeli R., and Gennaro M.L. 1997. Molecular cloning, purification and serological characterization of MPT63, a novel secreted antigen from Mycobacterium tuberculosis. Infect. Immun. 65: 16-23.

 

 

  
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